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Related Experiment Video

Updated: Dec 25, 2025

Surgical Techniques to Optimize Ovarian Reserve during Laparoscopic Cystectomy for Ovarian Endometrioma
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Intraoperative tranexamic acid to decrease blood loss during myomectomy: a randomized, double-blind,

Jessica Opoku-Anane1, Maria V Vargas2, Cherie Q Marfori2

  • 1Department of Obstetrics, Gynecology & Reproductive Sciences, University of California San Francisco, San Francisco, CA.

American Journal of Obstetrics and Gynecology
|April 2, 2020
PubMed
Summary
This summary is machine-generated.

Tranexamic acid (TXA) did not significantly reduce blood loss during myomectomy surgery. This antifibrinolytic agent showed no benefit in lowering perioperative bleeding or transfusion needs in women undergoing uterine fibroid removal.

Keywords:
antifibrinolyticsblood lossfibroidshemorrhagelaparoscopymyomasmyomectomyroboticstranexamic acidtransfusion

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Area of Science:

  • Gynecologic Surgery
  • Surgical Hemorrhage Control
  • Pharmacology

Background:

  • Myomectomy carries a substantial risk of hemorrhage.
  • Tranexamic acid (TXA) is an antifibrinolytic agent used to reduce surgical bleeding.
  • Its effectiveness in gynecologic surgery, specifically myomectomy, is not well-established.

Purpose of the Study:

  • To evaluate the impact of early intravenous tranexamic acid administration on perioperative bleeding.
  • To assess the effect of TXA on blood transfusion requirements in women undergoing myomectomy.
  • To investigate TXA's utility in minimizing blood loss during myomectomy procedures.

Main Methods:

  • A double-blinded, randomized, placebo-controlled trial was conducted.
  • Participants included women at risk for significant blood loss during myomectomy.
  • Patients received either intravenous tranexamic acid or saline placebo before surgery.

Main Results:

  • No significant difference in median estimated blood loss between TXA and placebo groups (200 mL vs. 240 mL).
  • No difference in surgical duration or change in hemoglobin levels.
  • While no patients in the TXA group required transfusion, 13.3% in the placebo group did (P=.11).

Conclusions:

  • Early intravenous tranexamic acid administration did not decrease blood loss in patients undergoing myomectomy.
  • The study found no significant benefit of TXA in reducing perioperative bleeding or transfusion rates.
  • Further research may be needed to explore TXA's role in specific gynecologic surgical contexts.