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Antibiotics administration during last trimester of pregnancy is associated with atopic dermatitis - a
Mihaela Panduru1,2,3, Adina Mihaela Epure4, Brindusa Cimpoca5
1"Carol Davila" University of Medicine and Pharmacy of Bucharest, Bucharest, Romania.
Insights
Prenatal antibiotic exposure, particularly during the third trimester, is linked to an increased risk of atopic dermatitis (AD) in children. This study highlights a significant association between specific timing of antibiotic use and AD development.
Area of Science:
- Obstetrics and Gynecology
- Pediatrics
- Dermatology
- Epidemiology
Background:
- Limited research exists on the relationship between antibiotic use during pregnancy and childhood atopic dermatitis (AD).
- Understanding this association is crucial for prenatal care and infant health.
- This study investigates the impact of intrauterine antibiotic exposure on AD occurrence.
Purpose of the Study:
- To examine the association between prenatal antibiotic administration and the development of atopic dermatitis in children.
- To determine if the timing of antibiotic exposure during pregnancy influences AD risk.
- To identify specific trimesters of antibiotic use linked to increased AD incidence.
Main Methods:
- A cross-sectional study involving 1046 subjects.
- Logistic regression analysis was used to evaluate antibiotic exposure during pregnancy.
- Adjustments were made for other risk factors and concurrent antibiotic exposures.
Main Results:
- Overall prenatal antibiotic administration showed a trend towards association with AD (OR = 1.28).
- Antibiotic use specifically during the third trimester was significantly associated with AD (OR = 2.94).
- This association remained independent after adjusting for other risk factors (OR = 2.64).
Conclusions:
- Third-trimester antibiotic administration during pregnancy is independently associated with atopic dermatitis in children.
- The timing of prenatal antibiotic exposure is a critical factor in AD development.
- Findings suggest a need for careful consideration of antibiotic use in late pregnancy.
Introduction:
Studies regarding antibiotics administration during pregnancy and atopic dermatitis (AD) in children are only few. In this context, the objective of our study was to investigate the potential association between the timing of intrauterine exposure to antibiotics or prenatal antibiotic administration in general and AD occurrence in children.
Methods:
This was a cross-sectional study in 1046 subjects. The exposure to antibiotics during pregnancy was initially evaluated using simple logistic regressions. Then, each period of antibiotics administration was adjusted with the other periods of antibiotics exposure (model 1) and with the other variables associated with AD in our database (model 2).
Results:
In simple logistic regression analysis, the administration of antibiotics during pregnancy, as a whole period, presented a trend of association with AD (OR = 1.28, %CI: 0.99 - 1.65). When we analyzed antibiotic administration during each trimester of pregnancy, only antibiotherapy during the 3rd trimester was associated with AD (OR = 2.94, %CI: 1.21 - 7.12). After adjusting with all the other important risk factors associated with AD in the database, antibiotics administration during the 3rd trimester of pregnancy was still independently associated with AD (OR=2.64, %CI: 1.01 - 6.91).
Conclusion:
Antibiotic administration during the 3rd trimester of pregnancy was independently associated with AD in children.
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