Myotonic muscular dystrophy in pregnancy

Area of Science:

• Neurology
• Genetics
• Obstetrics

Background:

• Myotonic muscular dystrophy (DM) is an autosomal dominant genetic disorder.
• DM presents with variable penetrance and progressive muscle weakness.
• Pregnancy in women with DM requires careful management due to potential complications.

Purpose of the Study:

• To describe the clinical course of pregnancy in two patients with myotonic muscular dystrophy.
• To review existing literature on the impact of pregnancy on myotonic muscular dystrophy.
• To highlight the complex interactions between DM and pregnancy outcomes.

Main Methods:

• Case report of two pregnant patients with myotonic muscular dystrophy.
• Comprehensive literature review on DM and pregnancy.
• Analysis of maternal and fetal outcomes.

Main Results:

• Pregnancy exacerbated myotonia and muscle weakness in the reported cases.
• Increased incidence of abortion, prematurity, fetal death, and labor dysfunction observed.
• Postpartum hemorrhage was a significant risk.

Conclusions:

• Myotonic muscular dystrophy significantly impacts pregnancy, increasing risks for both mother and fetus.
• Close monitoring and multidisciplinary care are essential for pregnant individuals with DM.
• Further research is needed to optimize management strategies for DM during pregnancy.