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Clinical Microfluidic Chip Platform for the Isolation of Versatile Circulating Tumor Cells
Published on: October 13, 2023
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Microfluidics and Nanomaterial-based Technologies for Circulating Tumor Cell Isolation and Detection.
Sheng-Jen Cheng1,2, Kuan Yu Hsieh1,2, Shiue-Luen Chen1,2
1Department of Electrical and Computer Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan.
Sensors (Basel, Switzerland)
|April 2, 2020
Summary
Early detection of cancer metastasis and recurrence is possible through identifying circulating tumor cells (CTCs). Microfluidics, nanomaterials, and surface modification are key to advancing CTCs diagnostics for better cancer treatment outcomes.
Area of Science:
- Biomedical Engineering
- Oncology
- Nanotechnology
Background:
- Cancer remains a leading global cause of death, with metastasis and recurrence significantly contributing to mortality.
- Circulating tumor cells (CTCs) are crucial in the spread and seeding of tumors, making their detection vital for early intervention.
Purpose of the Study:
- To review advancements in microfluidics for diagnosing circulating tumor cells (CTCs).
- To explore the role of nanomaterials and surface modification in CTCs detection.
- To emphasize the integrated use of microchannels, nanomaterials, and surface modification for effective CTCs isolation and detection.
Main Methods:
- Review of current microfluidics technologies for CTCs isolation and detection.
- Analysis of nanomaterial applications in enhancing diagnostic sensitivity.
- Examination of surface modification strategies for improved CTCs capture and identification.
Main Results:
- Microfluidics offers promising platforms for sensitive and specific CTCs detection.
- Nanomaterials and surface modifications significantly improve the efficiency of CTCs isolation and detection.
- Integration of these technologies is crucial for robust diagnostic tools.
Conclusions:
- Advancements in microfluidics, nanomaterials, and surface modification are pivotal for improving CTCs diagnostics.
- Early detection of metastasis and recurrence via CTCs analysis can enhance cancer cure rates.
- Further integration of these technologies holds great potential for clinical cancer management.
