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Updated: Dec 25, 2025

Techniques to Induce and Quantify Cellular Senescence
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Published on: May 1, 2017

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Sestrins induce natural killer function in senescent-like CD8+ T cells

Branca I Pereira1, Roel P H De Maeyer1, Luciana P Covre1,2

  • 1Division of Infection and Immunity, University College London, London, UK.

Nature Immunology
|April 2, 2020
PubMed
Summary

As we age, senescent CD8+ T cells gain innate-like killing abilities. Sestrins reprogram these cells by enabling NKG2D-DAP12 complex formation, enhancing cytotoxicity.

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