Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Resistance-pattern-analysis--a step toward predictable differentiated antibiotic therapy.

W Fegeler1, D Lintz, W Ritzerfeld

  • 1Institute of Medical Microbiology, Westphalien Wilhelms-University Münster.

Zentralblatt Fur Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology
|November 1, 1988
PubMed
Summary

Resistance-Pattern-Analysis (RPA) allows antibiotic susceptibility comparisons, independent of patient factors. Aztreonam demonstrated superior efficacy against tested bacterial isolates compared to amikacin and gentamicin.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early empiric antifungal therapy of infections in neutropenic patients comparing fluconazole with amphotericin B/flucytosine.

Mycoses·2017
Same author

Phylogenetic relationships matter: antifungal susceptibility among clinically relevant yeasts.

Antimicrobial agents and chemotherapy·2013
Same author

Species and susceptibility distribution of 1062 clinical yeast isolates to azoles, echinocandins, flucytosine and amphotericin B from a multi-centre study.

Mycoses·2012
Same author

Candidaemia in a European Paediatric University Hospital: a 10-year observational study.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2011
Same author

Susceptibility to cefuroxime 450 bacterial strains resistant to gentamicin.

Proceedings of the Royal Society of Medicine·2010
Same author

Catheter-associated aspergillosis of the chest wall following allogeneic hematopoietic stem cell transplantation.

Transplant infectious disease : an official journal of the Transplantation Society·2010

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Antibiotic susceptibility testing is crucial for effective treatment.
  • Patient and test-specific factors can complicate the interpretation of susceptibility results.
  • A standardized method is needed for objective antibiotic comparison.

Purpose of the Study:

  • To introduce and describe the Resistance-Pattern-Analysis (RPA) method.
  • To illustrate the RPA's utility in comparing antibiotic efficacy.
  • To demonstrate RPA's application in selecting empirical antibiotic therapy and cost-risk analysis.

Main Methods:

  • Resistance-Pattern-Analysis (RPA) was developed for objective comparison of antibiotic susceptibility data.
  • RPA was applied to analyze susceptibility results for 1526 bacterial isolates.

Related Experiment Videos

  • Antibiotics analyzed included aztreonam, gentamicin, and amikacin.

    • Main Results:

    • Aztreonam exhibited superior activity against all tested bacterial species compared to amikacin.
    • Aztreonam demonstrated the best results against Pseudomonadaceae when compared to gentamicin.
    • The study illustrated RPA's potential for comparative assessment and therapy selection.

    Conclusions:

    • Resistance-Pattern-Analysis (RPA) provides a robust method for comparing antibiotic effectiveness.
    • RPA facilitates informed antibiotic selection for both established and empirical therapies.
    • The method supports cost-risk analysis in medical microbiology and infectious disease management.