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Amiodarone-Induced Acute Liver Injury
Rajesh Essrani1, Shehriyar Mehershahi2, Rajesh Kumar Essrani2
1Department of Internal Medicine, Geisinger Medical Center, Danville, Pennsylvania, USA.
Abstract:
Amiodarone is a lipophilic structure with a half-life of 25-100 days. Long-term oral amiodarone is associated with photosensitivity, thyroid dysfunction, and pulmonary and hepatic toxicity. Intravenous amiodarone can lead to sweating, heating sensation, nausea, phlebitis at the injection site, and rarely acute hepatitis. This is a compelling case of a 60-year-old male who developed acute liver injury 24-36 h after starting amiodarone. All the possible causes of acute liver injury were ruled out, and his liver enzymes improved after discontinuing amiodarone.
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