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Regulation of the Ras-Related Signaling Pathway by Small Molecules Containing an Indole Core Scaffold: A Potential

Fei-Yu Chen1, Xiang Li1, Hong-Ping Zhu2

  • 1State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Frontiers in Pharmacology
|April 2, 2020
PubMed

Insights

Indole derivatives show promise in targeting aberrant Ras signaling pathways, crucial for cell development and implicated in malignant tumors. This review explores their mechanisms and potential as cancer treatment inhibitors.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • The Ras-related signaling pathway is vital for cell development and differentiation.
  • Aberrant activation of Ras is linked to tumor development and progression.
  • Indole derivatives are being investigated for their potential to modulate these pathways.

Purpose of the Study:

  • To review the role of indole derivatives in Ras-related signaling pathways.
  • To elucidate the regulatory mechanisms of indoles in key Ras pathways.
  • To discuss current and future therapeutic strategies targeting these pathways.

Main Methods:

  • Literature review of studies on indole derivatives and Ras signaling.
  • Analysis of regulatory mechanisms in isoprenylcysteine carboxyl methyltransferase-participant Ras membrane localization and Ras-GTP/Raf/MAPK pathways.
  • Synthesis of information on current treatment strategies.

Main Results:

  • Indole derivatives can target and interfere with aberrant Ras-related pathways.
  • Specific pathways discussed include Ras membrane localization and Ras-GTP/Raf/MAPK.
  • Mechanisms of action and regulatory roles of indoles are summarized.

Conclusions:

  • Indole derivatives hold potential as therapeutic agents for malignant tumors by targeting Ras pathways.
  • Further research into Ras-related signaling pathway inhibitors is warranted.
  • This review provides a foundation for developing novel cancer treatments.
Keywords:
Ras-Related signaling pathwayantitumorindoleregulatory mechanismsscreening and optimizing

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