Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is a Species?01:17

What is a Species?

49.1K
Overview
49.1K
Genetics of Speciation02:16

Genetics of Speciation

20.7K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
20.7K
Hybrid Zones02:29

Hybrid Zones

21.6K
Hybrid zones are narrow regions where two closely related species interact, mate, and produce hybrids. Relative to either parent species, hybrids may possess distinct phenotypic or genetic differences that impact their survival and reproductive success. The genetic variances introduced by hybridization influence species diversity and speciation processes within the hybrid zone.
21.6K
Formation of Species01:31

Formation of Species

44.4K
Speciation describes the formation of one or more new species from one or sometimes multiple original species. The resulting species are discrete from the parent species, and barriers to reproduction will typically exist. There are two primary mechanisms, speciation with and without geographic isolation—allopatric and sympatric speciation, respectively.
44.4K
Speciation Rates01:07

Speciation Rates

22.5K
Overview
22.5K
Physiological Barriers01:25

Physiological Barriers

4.9K
Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a sensitive real-time quaking-induced conversion (RT-QuIC) assay for application in prion-infected blood.

PloS one·2023
Same author

Conservation of vCJD Strain Properties After Extraction and In Vitro Propagation of PrP<sup>Sc</sup> from Archived Formalin-Fixed Brain and Appendix Tissues Using Highly Sensitive Protein Misfolding Cyclic Amplification.

Molecular neurobiology·2023
Same author

Fourth Report on Chicken Genes and Chromosomes 2022.

Cytogenetic and genome research·2023
Same author

Subclinical infection occurs frequently following low dose exposure to prions by blood transfusion.

Scientific reports·2022
Same author

Preclinical transmission of prions by blood transfusion is influenced by donor genotype and route of infection.

PLoS pathogens·2021
Same author

Identification of a homology-independent linchpin domain controlling mouse and bank vole prion protein conversion.

PLoS pathogens·2020
Same journal

Scientific Basis of Tolerable Daily Intake Derivation in Japan: Analysis of Study Types, Uncertainty Factors, and Critical Effect Levels in FSCJ Risk Assessment Reports.

Food safety (Tokyo, Japan)·2026
Same journal

U.S. FDA Regulatory Monitoring of Ochratoxin A in Human Foods: 2008-2022.

Food safety (Tokyo, Japan)·2026
Same journal

Occurrence of Natural Interspecific Hybrids in the Pufferfish, Genus <i>Takifugu</i>, and Their Tetrodotoxin-accumulating Tissues.

Food safety (Tokyo, Japan)·2026
Same journal

Occurrence of Human Norovirus and Hepatitis A Virus in Domestic Agricultural Waters.

Food safety (Tokyo, Japan)·2026
Same journal

Oxolinic Acid (Pesticides/Veterinary Medicinal Products).

Food safety (Tokyo, Japan)·2026
Same journal

Development of a Long-term Migration Test Method for Plastic Food Utensils, Containers, and Packaging.

Food safety (Tokyo, Japan)·2026
See all related articles

Related Experiment Video

Updated: Dec 25, 2025

Application of Impermeable Barriers Combined with Candidate Factor Soaked Beads to Study Inductive Signals in the Chick
08:04

Application of Impermeable Barriers Combined with Candidate Factor Soaked Beads to Study Inductive Signals in the Chick

Published on: November 17, 2016

9.7K

Evaluating the Species Barrier.

Jean C Manson1, Abigail B Diack1

  • 1Neurobiology Division, The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush, UK.

Food Safety (Tokyo, Japan)
|April 2, 2020
PubMed
Summary
This summary is machine-generated.

Transmissible Spongiform Encephalopathy (TSE) agents face a species barrier when moving between hosts. Evaluating this barrier requires comprehensive data from surveillance and research, as no single test is definitive.

Keywords:
PrPPrion transmissionSpecies barrierTransgenic modelsTransmissible Spongiform Encephalopathies (TSE)

More Related Videos

Assessing Transmissible Spongiform Encephalopathy Species Barriers with an In Vitro Prion Protein Conversion Assay
11:41

Assessing Transmissible Spongiform Encephalopathy Species Barriers with an In Vitro Prion Protein Conversion Assay

Published on: March 10, 2015

8.2K
At-Risk Butterfly Captive Propagation Programs to Enhance Life History Knowledge and Effective Ex Situ Conservation Techniques
07:10

At-Risk Butterfly Captive Propagation Programs to Enhance Life History Knowledge and Effective Ex Situ Conservation Techniques

Published on: February 11, 2020

7.5K

Related Experiment Videos

Last Updated: Dec 25, 2025

Application of Impermeable Barriers Combined with Candidate Factor Soaked Beads to Study Inductive Signals in the Chick
08:04

Application of Impermeable Barriers Combined with Candidate Factor Soaked Beads to Study Inductive Signals in the Chick

Published on: November 17, 2016

9.7K
Assessing Transmissible Spongiform Encephalopathy Species Barriers with an In Vitro Prion Protein Conversion Assay
11:41

Assessing Transmissible Spongiform Encephalopathy Species Barriers with an In Vitro Prion Protein Conversion Assay

Published on: March 10, 2015

8.2K
At-Risk Butterfly Captive Propagation Programs to Enhance Life History Knowledge and Effective Ex Situ Conservation Techniques
07:10

At-Risk Butterfly Captive Propagation Programs to Enhance Life History Knowledge and Effective Ex Situ Conservation Techniques

Published on: February 11, 2020

7.5K

Area of Science:

  • Veterinary Medicine
  • Neuroscience
  • Infectious Diseases

Background:

  • Transmissible Spongiform Encephalopathy (TSE) agents exhibit limited transmission between species, a phenomenon termed the species barrier.
  • Following initial transmission, these agents can adapt to a new host, enhancing subsequent within-species transmission.

Purpose of the Study:

  • To review the critical factors and methodologies for evaluating the species barrier of prion strains.
  • To highlight the necessity of a multi-faceted approach combining surveillance and research data.

Main Methods:

  • Review of existing literature on prion transmission and species barriers.
  • Analysis of in vivo and in vitro experimental approaches for assessing agent-host interactions.
  • Synthesis of surveillance data and research findings.

Main Results:

  • No single diagnostic test accurately predicts prion strain transmissibility across species.
  • Successful evaluation of the species barrier relies on integrating diverse data sources.
  • In vivo and in vitro methods provide crucial insights into agent-host dynamics.

Conclusions:

  • Assessing the species barrier for TSE agents is complex and requires a holistic evaluation.
  • Comprehensive data integration is essential for accurate risk assessment of prion diseases.
  • Future research should focus on refining methods for predicting interspecies transmission.