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Olfactory Assays for Mouse Models of Neurodegenerative Disease
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[Olfactory Dysfunctions: References to Neuropsychiatric Disorders and Diagnostics]
Sylvia Waldmann1, Katrin T Lübke2, Michael Pentzek3
1Zentrum für Krisenintervention, Psychiatrie Baselland.
Fortschritte Der Neurologie-Psychiatrie
|April 2, 2020
Summary
Olfactory deficits are common in psychiatric and neurodegenerative disorders like Major Depression, Schizophrenia, Alzheimer
Area of Science:
- Neuroscience
- Psychiatry
- Gerontology
Background:
- Olfactory deficits are increasingly recognized in psychiatric and neurodegenerative disorders.
- These deficits are observable through psychophysical, neurophysiological, and neuroanatomical assessments.
- Olfactory dysfunction patterns appear specific to the disorder, with links to brain regions governing emotion and olfaction in affective disorders.
Purpose of the Study:
- To review olfactory deficits reported in psychiatric and neurodegenerative conditions.
- To present and classify olfactory tests available in German-speaking countries for diagnosing these deficits.
- To provide empirical validation data for the Düsseldorf Odour Discrimination Test in a clinical setting.
Main Methods:
- Systematic review of literature on olfactory deficits in Major Depression, Schizophrenia, Alzheimer's Disease, and Parkinson's Disease.
- Classification of olfactory tests based on disorder-specific deficits.
- Empirical validation of the Düsseldorf Odour Discrimination Test.
Main Results:
- Converging evidence indicates olfactory perception changes in Major Depression, Schizophrenia, Alzheimer's, and Parkinson's Disease.
- Olfactory testing is proposed as a potential diagnostic marker.
- The Düsseldorf Odour Discrimination Test shows empirical validity in clinical populations.
Conclusions:
- Olfactory testing offers a valuable, objective diagnostic marker for psychiatric and neurodegenerative disorders.
- Standardized testing methods and interpretation guidelines are crucial for clinical application.
- Further research and validation of olfactory tests are warranted.
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