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Cistiside-M, a new protective agent.
M Minkova1, T Pantev, R Georgieva
1Research Institute of Nuclear Medicine, Radiobiology and Radiation Hygiene, Medical Academy, Sofia.
Acta Physiologica Et Pharmacologica Bulgarica
|January 1, 1988
Summary
The novel radioprotective agent Cistiside-M demonstrated significant efficacy in protecting mice against lethal gamma radiation. This compound exhibits low toxicity and a notable antiradiation effect across a broad dosage range.
Area of Science:
- Radiopharmacology
- Toxicology
- Radiation Biology
Background:
- Investigating novel radioprotective agents is crucial for mitigating radiation damage.
- Understanding the toxicological and pharmacological profiles of potential radioprotectors is essential for clinical application.
Purpose of the Study:
- To evaluate the radioprotective efficacy and toxicological properties of Cistiside-M (2-mercaptoethylamine adenosine-5-phosphate).
- To determine optimal dosage and assess the protective effects against gamma irradiation in mice.
Main Methods:
- Male mice (C57Bl and H lines) were administered Cistiside-M intraperitoneally before lethal gamma irradiation (137Cs source, 6-15 Gy).
- Radioprotective effects were quantified using 30-day survival, mean survival time, coefficient of protection alpha, S30, and dose-reduction factor (DRF).
Main Results:
- Cistiside-M exhibited low toxicity and a significant radioprotective effect over a wide dose range.
- Maximum radioprotection (75% survival) was observed at 1000 mg/kg, with a DRF of 1.6.
- A dose of 250 mg/kg resulted in a 50% survival rate and a therapeutic index of 5.6.
Conclusions:
- Cistiside-M possesses considerable radioprotective properties with low toxicity.
- The compound's complex structure likely contributes to its significant antiradiation effects.