Related Experiment Video
Updated: Dec 25, 2025
Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
Published on: October 20, 2016
Left Ventricular Global Longitudinal Strain as a Predictor for Left Ventricular Reverse Remodeling in Dilated
In Hyun Jung1,2, Jin Hye Park3, Jeong A Lee3
1Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Insights
Left ventricular global longitudinal strain (LV GLS) predicts left ventricular reverse remodeling (LVRR) in dilated cardiomyopathy (DCM) patients. An LV GLS of -10% is optimal for identifying LVRR in DCM patients with sinus rhythm.
Area of Science:
- Cardiology
- Echocardiography
- Cardiovascular Imaging
Background:
- Dilated cardiomyopathy (DCM) frequently leads to left ventricular reverse remodeling (LVRR).
- Left ventricular global longitudinal strain (LV GLS) is a sensitive measure of myocardial dysfunction.
- Predicting LVRR in DCM patients with sinus rhythm is crucial for prognosis.
Purpose of the Study:
- To evaluate if baseline LV GLS can predict LVRR in DCM patients with sinus rhythm.
- To determine the prognostic role of LV GLS in long-term follow-up of DCM patients.
- To identify an optimal LV GLS cut-off for predicting LVRR.
Main Methods:
- 160 DCM patients with sinus rhythm were enrolled.
- Retrospective analysis of medical records and echocardiographic data.
- Multivariate Cox analysis was used to assess predictors of LVRR.
Main Results:
- LVRR occurred in 28% of patients during a mean follow-up of 37.3 months.
- Baseline LV GLS showed a significant correlation with follow-up LVEF (r = 0.717; p < 0.001).
- LV GLS was an independent predictor of LVRR (HR: 1.474; p = 0.001).
Conclusions:
- LV GLS is an independent predictor of LVRR in DCM patients with sinus rhythm.
- An optimal LV GLS cut-off of -10% was identified for predicting LVRR.
- Baseline LV GLS is significantly correlated with follow-up LVEF, aiding in LVRR prediction.
Background:
A considerable number of patients with dilated cardiomyopathy (DCM) experience left ventricular reverse remodeling (LVRR). LV global longitudinal strain (LV GLS) offers sensitive and reproducible measurement of myocardial dysfunction. The authors sought to evaluate whether LV GLS at the time of diagnosis may predict LVRR in DCM patients with sinus rhythm and investigate its prognostic role in long-term follow-up in this population.
Methods:
We enrolled 160 DCM patients with sinus rhythm who had been initially diagnosed, evaluated, and followed at our institute. We analyzed their medical records and echocardiographic data.
Results:
During the mean follow-up duration of 37.3 ± 21.7 months, LVRR occurred in 28% of patients (n = 45). The initial LV ejection fraction (LVEF) of patients who recovered LV function was 26.1 ± 7.9%, which was not significantly different from the value of 27.1 ± 7.4% (p = 0.49) in those who did not recover. There was a moderate and highly significant correlation between baseline LV GLS (-%) and follow-up LVEF (r = 0.717; p < 0.001). Using multivariate Cox analysis, LV GLS (hazard ratio: 1.474, 95% confidence interval: 1.170-1.856; p = 0.001) was an independent predictor of LVRR.
Conclusions:
We demonstrated that LV GLS was an independent predictor for LVRR and the optimal cut-off point of LV GLS for LVRR was -10% in DCM patients with sinus rhythm. There was a significant correlation between baseline LV GLS and follow-up LVEF.
More Related Videos
06:34Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
Published on: October 28, 2020
11:50High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
Published on: July 9, 2010
Related Concept Videos
01:20Mitral Regurgitation I: Introduction
01:29Heart Failure II: Pathophysiology