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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling.

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Related Experiment Video

Updated: Jul 25, 2026

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling
08:28

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Published on: May 21, 2020

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Bone remodeling platforms: Understanding the need for multicellular lab-on-a-chip systems and predictive agent-based

Sharon L Truesdell1, Marnie M Saunders1

  • 1The Bone Biomechanics and Mechanobiology Lab, Department of Biomedical Engineering, The University of Akron, Akron, OH, USA.

Mathematical Biosciences and Engineering : MBE
|April 3, 2020
PubMed
Summary

Developing advanced bone remodeling platforms is crucial for studying cell interactions. This research proposes complex lab-on-a-chip systems and agent-based models for deeper insights into bone biology.

Keywords:
agent-based modelsbone remodelingcellular automataconditioned mediumlab-on-a-chipmechanotransduction

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Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Computational Biology

Background:

  • Bone remodeling is a complex physiological process regulated by intricate multicellular interactions.
  • Current experimental models often lack the complexity to fully investigate these interactions.
  • Understanding bone remodeling is vital for treating bone diseases and injuries.

Purpose of the Study:

  • To highlight the necessity for sophisticated bone remodeling platforms.
  • To explore the development of lab-on-a-chip systems for bone remodeling research.
  • To advocate for advanced multicellular models and mathematical modeling integration.

Main Methods:

  • Development of microfluidic lab-on-a-chip systems.
  • Investigation of multicellular interactions in bone remodeling.
  • Application of mathematical modeling, including agent-based models and cellular automata.

Main Results:

  • Established the need for complex platforms to study bone cell communication.
  • Proposed lab-on-a-chip systems as a viable approach for advanced bone remodeling research.
  • Identified agent-based modeling as a powerful tool for simulating bone remodeling dynamics.

Conclusions:

  • Advancing bone remodeling research requires complex, multicellular models.
  • Integration of microfluidics, cell biology, and computational modeling is essential.
  • Collaborative, multidisciplinary efforts are key to significant progress in bone biology.