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Updated: Dec 25, 2025
Isolated Lung Perfusion System in the Rabbit Model
Published on: July 15, 2021
Effect of ex vivo lung perfusion on storage of isolated lungs
1Department of Thoracic Surgery, Wuxi People's Hospital, Wuxi 214023, China.
Background:
To establish a stable ex vivo lung perfusion (EVLP) model and determine the preservation effect of the EVLP technique on donor lungs in vitro.
Methods:
EVLP was performed on nonacceptable human donor and porcine lungs, and during perfusion, the oxygenation index was assessed and blood gas analysis was performed.
Results:
After 4 h of EVLP of nonacceptable human donor and porcine lungs, lung function parameters remained stable, and lung energy metabolism was improved to a certain extent.
Conclusions:
EVLP can suitably maintain donor lungs in vitro for transplantation and is an effective method for ex vivo preservation of donor lungs.
