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Updated: Dec 25, 2025

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
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The role of angiotensin receptor blockers in CVD risk management

Leonardo Grabinski Bottino1, Flávio Danni Fuchs1,2

  • 1School of Medicine, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil.

Expert Review of Cardiovascular Therapy
|April 3, 2020
PubMed

Insights

Angiotensin receptor blockers (ARBs) show limited effectiveness in preventing cardiovascular events and deaths. New concerns include potential links to cancer and suicide, warranting further investigation.

Area of Science:

  • Cardiology
  • Pharmacology
  • Public Health

Background:

  • Angiotensin receptor blockers (ARBs) are guideline-recommended for hypertension.
  • Recent concerns question their effectiveness and safety profile.

Purpose of the Study:

  • To review ARBs' effectiveness in preventing major cardiovascular outcomes.
  • To examine emerging adverse effects associated with ARBs.

Main Methods:

  • Review of seven randomized controlled trials (RCTs).
  • Analysis of several large-scale meta-analyses.
  • Inclusion of observational studies and reports on drug contamination.

Main Results:

  • ARBs were not superior to placebo in preventing all-cause deaths and cardiovascular events.
  • Retractions of three RCTs raise concerns about data reliability.
  • Potential associations with increased cancer risk and suicide incidence were noted.
  • Carcinogenic contaminants found in several ARB batches.

Conclusions:

  • ARBs lack proven efficacy in reducing cardiovascular disease (CVD) risk.
  • Current evidence does not support ARBs as preferential hypertension treatments.
  • Further research is needed on ARBs' links to suicide and cancer.

Keywords:
Angiotensin receptor blockerscancercardiovascular diseasehypertensionsuicide

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