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Published on: June 10, 2025
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Vocal Biomarker Is Associated With Hospitalization and Mortality Among Heart Failure Patients.
Elad Maor1,2, Daniella Perry3, Dana Mevorach3
1Chaim Sheba Medical Center Tel Hashomer Israel.
Journal of the American Heart Association
|April 3, 2020
Summary
Voice analysis can predict adverse outcomes in congestive heart failure (CHF) patients. A novel vocal biomarker showed a significant association with increased mortality and hospitalizations in CHF individuals.
Area of Science:
- Cardiology
- Biomedical Engineering
- Digital Health
Background:
- Congestive heart failure (CHF) management relies on monitoring patient status.
- Current monitoring methods may not capture subtle physiological changes indicative of worsening conditions.
Purpose of the Study:
- To evaluate the association between voice signal analysis and adverse outcomes in patients with congestive heart failure (CHF).
Main Methods:
- A cohort of 10,583 patients with chronic conditions, including CHF, was analyzed.
- 223 acoustic features were extracted from 20-second speech samples.
- A vocal biomarker was developed and validated on a CHF cohort (N=2267) with a median follow-up of 20 months.
Main Results:
- Higher quartiles of the vocal biomarker were associated with increased cumulative probability of death (P<0.001).
- Each SD increase in the biomarker correlated with a 32% increased risk of death (P<0.001).
- The biomarker independently predicted hospitalizations (P<0.001).
Conclusions:
- A noninvasive vocal biomarker is significantly associated with adverse outcomes, including mortality and hospitalizations, in CHF patients.
- Voice analysis shows potential as a tool for telemedicine and enhanced CHF patient care.
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