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Updated: Dec 25, 2025

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

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[Value of absolute quantification of myocardial perfusion by PET in detecting coronary microvascular disease in

P Wu1, X S Guo1, X Zhang2

  • 1Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Shanxi Key Laboratory of Molecular Imaging, Taiyuan 030001, China.

Zhonghua Xin Xue Guan Bing Za Zhi
|April 3, 2020
PubMed

Insights

Coronary microvascular disease (CMVD) occurs in non-obstructive arteries in both obstructive and non-obstructive coronary artery disease patients. However, CMVD prevalence is higher in obstructive coronary artery disease patients.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Diagnostic Imaging

Background:

  • Coronary microvascular disease (CMVD) is a significant cause of angina.
  • Its prevalence and characteristics in relation to obstructive versus non-obstructive coronary artery disease require further clarification.

Purpose of the Study:

  • To compare the incidence of CMVD in patients with non-obstructive versus obstructive coronary arteries.
  • To investigate CMVD in non-obstructive segments within the obstructive group.

Main Methods:

  • Retrospective analysis of 97 angina patients undergoing PET myocardial perfusion and coronary anatomy imaging.
  • Patients categorized into non-obstructive (no stenosis ≥50%) and obstructive (≥1 stenosis ≥50%) groups.
  • CMVD defined by coronary flow reserve (CFR) < 2.90 and stress myocardial blood flow (SMBF) < 2.17 ml·min(-1)·g(-1).

Main Results:

  • CMVD incidence was higher in non-obstructive arteries of the obstructive group compared to non-obstructive arteries of the non-obstructive group (47.1% vs. 25.5%).
  • Overall CMVD incidence was similar between patients with non-obstructive and obstructive coronary arteries (44% vs. 33.3%).
  • Rest myocardial blood flow, SMBF, and CFR were not significantly different between the two main groups.

Conclusions:

  • Coronary microvascular disease is present in non-obstructive coronary arteries of both patient groups.
  • Patients with obstructive coronary arteries exhibit a higher prevalence of CMVD.
  • The severity of CMVD appears similar between the obstructive and non-obstructive groups.

Keywords:
Coronary artery diseaseCoronary flow reserveMicrocirculationPositron-emission tomography

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