Related Experiment Video
Updated: Dec 25, 2025

Author Spotlight: Development and Characterization of a Mouse Model for Abdominal Aortic Aneurysm
Published on: August 2, 2024
Effect of Statin Therapy on Abdominal Aortic Aneurysm Growth Rate and Mortality: A Systematic Review and
ZhongJie Pan1, HongYu Cui1, Nan Wu1
1Vascular Department, TianJin Union Medical Center, Tianjin, People's Republic of China.
Background:
The aim of this study is to explore the effects of statin therapy with the abdominal aortic aneurysm (AAA) growth rate and mortality.
Methods:
Databases of PubMed, EMBASE, Ovid, Wanfang, and China National Knowledge Infrastructure were investigated for eligible literatures from their establishments to May 2019. Included studies were selected according to precise eligibility criteria. Statistical analysis was performed by RevMan 5.3 software.
Results:
Fourteen studies with a total of 38,749 patients of whom 15,993 underwent statins treatment and 22,756 underwent placebo or conventional therapy were eligible for meta-analysis. The pooled results indicated that the statin use was related to a significantly lower AAA growth rate (mean difference = -1.5 mm/year, 95% confidence interval [CI] = -1.99 to -1.02, P < 0.00001). In addition, statins can significantly reduce the short-term mortality (in-hospital or 30 days) (odds ratio = 0.63, 95% CI = 0.56-0.7, P < 0.00001) and long-term mortality (1 year after surgery) after AAA repair (odds ratio = 0.67, 95% CI = 0.61-0.74, P < 0.00001).
Conclusions:
This meta-analysis revealed that statin therapy can reduce the risks of AAA growth rates and mortality. However, due to its significant heterogeneity in the included studies, the consequence should be understood with caution.
More Related Videos
Related Concept Videos
Atherosclerosis III: Management
Aneurysm III: Interprofessional Care
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Aortic Regurgitation III: Medical Management
Atherosclerosis IV: Nursing Management

