Related Experiment Video
Updated: Dec 25, 2025
11:31
Author Spotlight: Image-Based Methods to Study Membrane Trafficking Events in Stomatal Lineage Cells
Published on: May 12, 2023
1.5K
"Make way": Pathogen exploitation of membrane traffic
Julia Noack1, Shaeri Mukherjee1
1Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, 94143, USA; George Williams Hooper Foundation, University of California, San Francisco, San Francisco, CA, 94143, USA.
Current Opinion in Cell Biology
|April 3, 2020
Summary
Intracellular pathogens hijack host cell membrane trafficking for survival and replication. Studying these interactions reveals new cell biology and potential therapeutic targets.
Area of Science:
- Microbiology
- Cell Biology
- Immunology
Background:
- Intracellular pathogens employ sophisticated strategies to manipulate host cells for survival and propagation.
- Exploitation of host membrane trafficking pathways is crucial for pathogen entry, niche establishment, nutrient acquisition, and immune evasion.
Purpose of the Study:
- To investigate the intricate mechanisms by which intracellular pathogens target and manipulate host cell membrane trafficking.
- To highlight the discovery of novel cellular processes and potential therapeutic avenues arising from studying pathogen-host interactions.
Main Methods:
- Analysis of host-pathogen interactions at the molecular and cellular level.
- Utilizing advanced microscopy and biochemical assays to track pathogen entry and intracellular trafficking.
- Investigating host cell ubiquitination and mitophagy pathways in response to infection.
Main Results:
- Identification of pathogen-specific manipulation of endocytic and exocytic pathways.
- Discovery of a noncanonical ubiquitination mechanism exploited by pathogens.
- Characterization of a novel mitophagy receptor involved in pathogen clearance or persistence.
Conclusions:
- Pathogen exploitation of membrane trafficking offers insights into fundamental cell biology.
- Understanding these interactions is vital for developing novel antimicrobial therapeutics.
- This research bridges host-pathogen interactions with core cellular mechanisms like ubiquitination and mitophagy.
Related Concept Videos
01:44Introduction to Membrane Traffic
9.0K
The ER, Golgi apparatus, endosomes, and lysosomes work in tandem to modify, sort, and package proteins and lipids. An integrated membrane trafficking network facilitates the back and forth shuttling of molecules within different organelles in the same cell or across the cell membrane.
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
9.0K
01:20Receptor-mediated Endocytosis
7.3K
Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
7.3K
01:39Receptor-mediated Endocytosis
110.0K
Overview
110.0K
01:44The Significance of Membrane Transport
40.8K
The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
40.8K
01:24Cellular Membranes and Drug Transport
1.3K
Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
1.3K
01:10Intracellular Movement of Viruses and Bacteria
3.3K
Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
3.3K