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Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation
Published on: November 10, 2023
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Lymphoproliferative disorder in a lung transplant recipient
Hassan A Haji1, Douglas S Corwin2, Jennifer Y So1
1Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
BMJ Case Reports
|April 3, 2020
Summary
Post-transplantation lymphoproliferative disorder (PTLD) is rare after organ transplants. This case highlights PTLD presenting as GI bleeding and pain in a lung transplant recipient, potentially linked to alemtuzumab induction and Epstein-Barr virus (EBV).
Area of Science:
- Immunology
- Oncology
- Transplantation Medicine
Background:
- Post-transplantation lymphoproliferative disorder (PTLD) is an uncommon but serious complication following solid organ transplantation.
- Risk factors for PTLD include Epstein-Barr virus (EBV) serologic status, with high-risk donor/recipient serologies increasing susceptibility.
- Alemtuzumab induction is used in some solid organ transplantations, but its role in PTLD development requires further investigation.
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