Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

DNA as a Genetic Template02:05

DNA as a Genetic Template

9.1K
9.1K
DNA as a Genetic Template02:05

DNA as a Genetic Template

27.2K
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
27.2K
DNA Packaging00:58

DNA Packaging

111.7K
Overview
111.7K
DNA Helicases00:55

DNA Helicases

23.6K
DNA unwinding helicase enzymes are a type of motor protein. Motor proteins can translocate along filaments or polymers using energy generated from ATP hydrolysis. Helicases are involved in all the important cellular processes where DNA unwinding is required, such as DNA replication, repair, recombination, and transcription. They are present in all living organisms, but vary in their structure, function, and mechanism of action. For example, in prokaryotes, DnaB helicase binds and translocates...
23.6K
DNA Topoisomerases02:02

DNA Topoisomerases

34.3K
Topoisomerases are enzymes that relax overwound DNA molecules during various cell processes, including DNA replication and transcription. These enzymes regulate positive and negative DNA supercoiling without changing the nucleotide sequence. DNA overwinding in a clockwise direction results in positively supercoiled DNA, whereas underwinding in a counterclockwise direction produces negatively supercoiled DNA.
Types and Mechanism of action
Topoisomerases are divided into two main types. ...
34.3K
DNA Base Pairing02:27

DNA Base Pairing

31.2K
31.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-omics-guided metabolic engineering of Limosilactobacillus reuteri for high-level 3-hydroxypropionaldehyde production from glucose.

Microbial cell factories·2026
Same author

Phase-Resolved Dual Control of Phenol Photodissociation at the Air-Water Interface From Structure-Resolved Statistics.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Predicting protein-protein interaction sites based on dynamic perception mechanism within a hierarchical E(n)-equivariant graph.

Briefings in bioinformatics·2026
Same author

Modified chitosan micelles improving physical stability, sustained release, and antibacterial activity of fir essential oil: performance optimization and mechanistic insights.

Food chemistry·2026
Same author

Comprehensive whole-genome characterization of SARS-CoV-2 strains in Jining China 2024-2025.

Frontiers in microbiology·2026
Same author

Directly Encrypting DNA Sequences for Secure DNA Storage via Automata Cryptography.

IEEE transactions on nanobioscience·2026
Same journal

RETRACTED: Kim et al. The Angiogenesis Inhibitor ALS-L1023 from Lemon-Balm Leaves Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease Through Regulating the Visceral Adipose-Tissue Function. <i>Int. J. Mol. Sci.</i> 2017, <i>18</i>, 846.

International journal of molecular sciences·2026
Same journal

Correction: Mahmud et al. Thymoquinone Attenuates NF-κβ Signalling Activation in Retinal Pigment Epithelium Cells Under AMD-Mimicking Conditions. <i>Int. J. Mol. Sci.</i> 2025, <i>26</i>, 11473.

International journal of molecular sciences·2026
Same journal

Correction: Borovikov et al. The Twisting and Untwisting of Actin and Tropomyosin Filaments Are Involved in the Molecular Mechanisms of Muscle Contraction, and Their Disruption Can Result in Muscle Disorders. <i>Int. J. Mol. Sci</i>. 2025, <i>26</i>, 6705.

International journal of molecular sciences·2026
Same journal

Correction: Molagoda et al. Flavonoid Glycosides from <i>Ziziphus jujuba</i> var. <i>inermis</i> (Bunge) Rehder Seeds Inhibit α-Melanocyte-Stimulating Hormone-Mediated Melanogenesis. <i>Int. J. Mol. Sci.</i> 2021, <i>22</i>, 7701.

International journal of molecular sciences·2026
Same journal

Correction: Guo et al. Integrated Transcriptomic and Metabolomic Analysis Reveals the Molecular Regulatory Mechanism of Flavonoid Biosynthesis in Maize Roots Under Lead Stress. <i>Int. J. Mol. Sci.</i> 2024, <i>25</i>, 6050.

International journal of molecular sciences·2026
Same journal

Correction: Chang et al. Improvement of Carbon Tetrachloride-Induced Acute Hepatic Failure by Transplantation of Induced Pluripotent Stem Cells Without Reprogramming Factor c-Myc. <i>Int. J. Mol. Sci.</i> 2012, <i>13</i>, 3598-3617.

International journal of molecular sciences·2026
See all related articles

Related Experiment Video

Updated: Dec 25, 2025

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

4.7K

An Intelligent Optimization Algorithm for Constructing a DNA Storage Code: NOL-HHO.

Qiang Yin1, Ben Cao1, Xue Li1

  • 1The Key Laboratory of Advanced Design and Intelligent Computing, Ministry of Education, School of Software Engineering, Dalian University, Dalian 116622, China.

International Journal of Molecular Sciences
|April 3, 2020
PubMed
Summary
This summary is machine-generated.

Researchers developed an improved Harris hawks optimization algorithm (NOL-HHO) to enhance DNA data storage. This method optimizes DNA sequences, boosting storage capacity and promoting DNA data storage technology.

Keywords:
DNA coding designDNA storageHHO algorithmOBL

More Related Videos

Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

7.4K
Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

15.0K

Related Experiment Videos

Last Updated: Dec 25, 2025

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

4.7K
Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

7.4K
Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

15.0K

Area of Science:

  • Biotechnology
  • Computer Science
  • Bioinformatics

Background:

  • DNA molecules offer high density, large capacity, and long-term stability, making them promising for large-scale data storage.
  • DNA sequence design for storage must adhere to constraints like no-runlength, GC-content, and Hamming distance to prevent hybridization issues.

Purpose of the Study:

  • To improve the Harris hawks optimization algorithm (HHO) for designing DNA sequences for data storage.
  • To enhance the coding lower bounds for DNA storage, thereby increasing storage capacity and code rate.

Main Methods:

  • A novel nonlinear control parameter strategy and a random opposition-based learning strategy were integrated into the HHO algorithm, creating the NOL-HHO algorithm.
  • The enhanced NOL-HHO algorithm was tested on 23 benchmark functions to evaluate its performance in optimization tasks relevant to DNA storage.

Main Results:

  • The NOL-HHO algorithm demonstrated superior global exploration capabilities and maintained a smoother transition between exploration and exploitation compared to other algorithms.
  • The algorithm successfully obtained improved coding lower bounds for DNA storage applications.

Conclusions:

  • The enhanced NOL-HHO algorithm effectively optimizes DNA sequences for data storage by addressing local optima issues.
  • Improvements in coding lower bounds directly enhance DNA storage capacity and code rate, advancing DNA data storage technology.