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Nonproteinuric diabetic kidney disease
Masayuki Yamanouchi1,2,3,4, Kengo Furuichi5, Junichi Hoshino6,7
1Nephrology Center, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo, 105-8470, Japan. m.yamanouchi@toranomon.gr.jp.
Clinical and Experimental Nephrology
|April 3, 2020
Summary
Diabetic kidney disease often causes proteinuria, but some patients lose kidney function without it. This review explores the clinical features, pathology, and outcomes of this nonproteinuric diabetic kidney disease.
Area of Science:
- Nephrology
- Endocrinology
- Diabetology
Background:
- Diabetic kidney disease (DKD) is a major complication of diabetes.
- Proteinuria is traditionally viewed as a key indicator of DKD and predictor of renal decline.
- A significant subset of diabetic patients exhibit renal function loss without proteinuria, termed nonproteinuric DKD.
Purpose of the Study:
- To consolidate and review existing knowledge on nonproteinuric diabetic kidney disease.
- To describe the clinical and pathological characteristics of this DKD phenotype.
- To evaluate the renal prognosis and mortality associated with nonproteinuric DKD.
Main Methods:
- Literature review of clinical studies and pathological findings.
- Analysis of data on renal function, proteinuria, and patient outcomes.
- Synthesis of information on disease progression and mortality in nonproteinuric DKD patients.
Main Results:
- Nonproteinuric DKD represents a distinct clinical entity within diabetic nephropathy.
- Clinical manifestations and pathological findings in nonproteinuric DKD can vary.
- Prognosis and mortality rates in nonproteinuric DKD require further elucidation but are significant.
Conclusions:
- Nonproteinuric DKD is an increasingly recognized condition in both type 1 and type 2 diabetes.
- Further research is crucial to fully understand the mechanisms, prognosis, and optimal management of nonproteinuric DKD.
- Recognizing this phenotype is essential for comprehensive patient care and research in diabetic kidney disease.
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