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Can reproductive genetic manipulation save lives?

G Owen Schaefer1

  • 1Centre for Biomedical Ethics, Yong Loo Lin School of Medicine, National University of Singapore, Block MD11, Clinical Research Centre, #02-03, 10 Medical Drive, Singapore, 117597, Singapore. medgos@nus.edu.sg.

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Summary

Reproductive genetic manipulation technologies, such as mitochondrial replacement and germline CRISPR, can be life-saving from a population health viewpoint. This challenges the notion that these interventions are not life-saving because no individual would suffer more without them.

Keywords:
CRISPRGenetic manipulationLife-savingMitochondrial replacement therapy

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Area of Science:

  • Bioethics
  • Reproductive Medicine
  • Genetics

Background:

  • Debate exists on whether reproductive genetic manipulation is life-saving.
  • Counterarguments state no individual would suffer more or die sooner without intervention.
  • This perspective overlooks population health implications.

Purpose of the Study:

  • To argue that reproductive genetic manipulations can be life-saving.
  • To establish the therapeutic value of these technologies from a population health perspective.
  • To address the validity of popular reports on life-saving potential.

Main Methods:

  • Philosophical argumentation.
  • Analysis of population health concepts.
  • Critique of counterfactual reasoning in bioethics.

Main Results:

  • Reproductive genetic manipulations can be considered life-saving when viewed through a population health lens.
  • These technologies possess therapeutic value by potentially improving overall population health outcomes.
  • The claim that these interventions are not life-saving is challenged.

Conclusions:

  • Reproductive genetic manipulation technologies, including mitochondrial replacement and germline CRISPR, may be life-saving.
  • A population health perspective is crucial for evaluating the life-saving potential and therapeutic value of these interventions.
  • Further empirical validation is needed for popular claims regarding life-saving and disease-preventing capabilities.