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Gasdermin family: a promising therapeutic target for cancers and inflammation-driven diseases

Danbin Wu1, Yefei Chen1, Yingxin Sun1

  • 1School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, People's Republic of China.

Journal of Cell Communication and Signaling
|April 3, 2020
PubMed

Insights

The gasdermin family proteins are key executors of programmed cell death, releasing inflammatory cytokines. Their roles in cancer and inflammatory diseases highlight their potential as therapeutic targets.

Area of Science:

  • Molecular Biology
  • Immunology
  • Cell Biology

Background:

  • The gasdermin family comprises proteins involved in regulating cell death pathways.
  • These proteins are increasingly recognized for their roles in various physiological and pathological processes.

Purpose of the Study:

  • To review recent advancements in gasdermin family research.
  • To discuss the expression patterns and biological functions of gasdermin family members.

Main Methods:

  • Literature review of current research on gasdermin family.
  • Analysis of studies detailing gasdermin expression and function.

Main Results:

  • Gasdermin family members exhibit distinct expression patterns.
  • Most gasdermins possess pore-forming activity, mediating programmed cell death and cytokine release.
  • These proteins are implicated in the pathogenesis of cancers and inflammation-driven diseases.

Conclusions:

  • Gasdermin family members are crucial regulators of cell death and inflammation.
  • Their involvement in diseases suggests significant potential as therapeutic targets for cancer and inflammatory conditions.
Keywords:
ApoptosisCancerGasdermin familyInflammation-driven diseasePyroptosis

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