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Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
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Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Published on: December 19, 2020

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Differences between COVID-19 and suspected then confirmed SARS-CoV-2-negative pneumonia: A retrospective study from a

Xinyi Chen1, Yi Yang2, Min Huang3

  • 1Department of Pathology, Qingdao Central Hospital, The Second Affiliated Hospital of Qingdao University Medical College, Qingdao, China.

Journal of Medical Virology
|April 3, 2020
PubMed

Insights

This study identified key differences between COVID-19 patients and controls. Younger age, Wuhan exposure, fever, cough, and specific lab values like procalcitonin, urea, and creatinine help distinguish severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Area of Science:

  • Infectious Diseases
  • Clinical Medicine
  • Epidemiology

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, emerged in Wuhan, China.
  • Distinguishing between SARS-CoV-2-positive and negative patients is crucial for effective management.
  • Early identification of clinical and laboratory markers aids in patient stratification.

Purpose of the Study:

  • To identify distinguishing features between COVID-19 patients and SARS-CoV-2-negative controls.
  • To compare clinical characteristics and routine blood workup parameters.
  • To establish predictors for differentiating COVID-19 cases.

Main Methods:

  • Retrospective comparison of data from 78 COVID-19 patients and 26 control patients.
  • Analysis of demographic data, exposure history, symptoms (fever, cough), and laboratory parameters (procalcitonin, urea, creatinine).
  • Statistical analysis using t-tests, chi-squared tests, and P-values to determine significance.

Main Results:

  • COVID-19 patients were younger and more likely to report Wuhan exposure (P < .001).
  • Fever and cough were more prevalent in COVID-19 patients.
  • COVID-19 patients showed significantly lower procalcitonin levels (P < .05) and were more likely to have normal or decreased urea and creatinine levels compared to controls (P < .05).

Conclusions:

  • Younger age, Wuhan exposure, fever, and cough are significant indicators of COVID-19.
  • Subtle changes in routine blood workup, including lower procalcitonin and normal/decreased urea and creatinine, help differentiate COVID-19 from controls.
  • These findings aid in the early clinical distinction of SARS-CoV-2 infection.

Keywords:
Coronavirus disease 2019 (COVID-19)laboratory testprocalcitoninsuspected then confirmed SARS-CoV-2-negative pneumoniasymptoms

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