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Updated: Dec 25, 2025
An Inexpensive Adaptation of a Commercial Microwave Reactor for Solid Phase Peptide Synthesis
Published on: November 22, 2024
Methods and Approaches for the Solid-Phase Synthesis of Peptide Alcohols
Fernando J Ferrer-Gago1, Li Quan Koh1
1p53 Laboratory, Agency for Science Technology and Research (A*STAR) 8A Biomedical Grove, #06-04/05 Neuros/Immunos., Singapore, 138648, Singapore.
Abstract:
Many methods have been developed for attaching an alcohol functionality to a solid support. However, not all of these methods are used to obtain peptide alcohols. In this Minireview, we will discuss several of the most important methods and approaches for the synthesis of peptide alcohols and the attachment of hydroxy groups to a solid support for the synthesis of cyclic peptides. Some of the methods include the use of functionalized Wang resin and the attachment of an alcohol to an enol ether resin. We also discuss the use of the chlorotrityl resin, one of the most common linkers used to obtain peptide alcohols. In addition, we outline the recently developed resins with the Rink, Ramage and Sieber handles. The majority of these methods have been used to synthesize many important drugs, such as octreotide and the antibiotic peptaibols.
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