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The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
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Rapid and Scalable Access to Sequence-Controlled DHDM Multiblock Copolymers by FLP Polymerization.

Yun Bai1, Huaiyu Wang1, Jianghua He1

  • 1State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, Jilin, 130012, China.

Angewandte Chemie (International Ed. in English)
|April 3, 2020
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Summary

A novel frustrated Lewis pair (FLP) polymerization strategy enables rapid, scalable synthesis of sequence-controlled multiblock copolymers at room temperature. This method achieves high block numbers and molecular weights without additional initiators or catalysts.

Keywords:
frustrated Lewis pairsliving polymerizationmultiblock copolymersorganophosphorus superbasesequence control

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Area of Science:

  • Polymer Chemistry
  • Organometallic Chemistry
  • Materials Science

Background:

  • Frustrated Lewis pairs (FLPs) are reactive species formed between Lewis acids and bases that do not fully associate.
  • FLPs have shown promise in catalysis and small molecule activation.
  • Developing efficient polymerization methods for complex polymer architectures remains a challenge.

Purpose of the Study:

  • To present a novel FLP-based polymerization strategy for synthesizing sequence-controlled multiblock copolymers.
  • To demonstrate the rapid and scalable nature of this method at room temperature.
  • To achieve high block numbers and molecular weights in synthesized copolymers.

Main Methods:

  • Utilized an immortal N-(diphenylphosphanyl)-1,3-diisopropyl-4,5-dimethyl-1,3-dihydro-2H-imidazol-2-imine/diisobutyl (2,6-di-tert-butyl-4-methylphenoxy) aluminum (P(NIi Pr)Ph2 /(BHT)Ali Bu2 ) based FLP.
  • Employed a room-temperature polymerization process without additional initiators or catalysts.
  • Controlled copolymer sequence and block numbers through precise monomer addition.

Main Results:

  • Successfully synthesized a tripentacontablock copolymer (n=53) with a molecular weight of 310 kg mol⁻¹ in 30 minutes.
  • Achieved the highest reported block number (n=53) for FLP polymerization.
  • Demonstrated precise control over monomer sequence and block numbers, enabling tailored copolymer properties.

Conclusions:

  • The presented FLP polymerization strategy offers a rapid, scalable, and efficient route to sequence-controlled multiblock copolymers.
  • This method provides a powerful tool for designing polymers with precisely tuned properties.
  • The approach eliminates the need for complex synthetic procedures and additional initiators/catalysts.