Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Multicentric reticulohistiocytosis.

Y C Giam¹, B H Ong

¹Middle Road Hospital, Singapore.

Annals of the Academy of Medicine, Singapore

|October 1, 1988

Summary

This report details the first diagnosed case of multicentric reticulohistiocytosis, a benign histiocytic disorder, presenting without arthritis. Methotrexate treatment proved ineffective for this rare condition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Management of patent foramen ovale in embolic stroke of undetermined source patients: Malaysian experts' consensus.

The Medical journal of Malaysia·2023

Same author

A prospective cross-sectional study of anxiety and depression in patients with psoriasis in Singapore.

Journal of the European Academy of Dermatology and Venereology : JEADV·2016

Same author

Filaggrin mutations are associated with recurrent skin infection in Singaporean Chinese patients with atopic dermatitis.

The British journal of dermatology·2011

Same author

Substrate effects on surface morphologies and magnetic properties of nanostructured FePt thin films.

Journal of nanoscience and nanotechnology·2011

Same author

Wide spectrum of filaggrin-null mutations in atopic dermatitis highlights differences between Singaporean Chinese and European populations.

The British journal of dermatology·2011

Same author

Juvenile psoriasis in European and Asian children: similarities and differences.

The British journal of dermatology·2011

Area of Science:

Dermatology
Rheumatology
Pathology

Background:

Multicentric reticulohistiocytosis (MCHR) is a rare, benign proliferative histiocytic disorder.
Characterized by a distinctive triad of dermatoarthritis, extensive red nodules, and rheumatoid-like arthritis.
Histological features include multinucleated giant cells with ground-glass cytoplasm and mononuclear histiocytes in granulomatous infiltrates.

Observation:

First reported case of MCHR diagnosed at Middle Road Hospital in 1987.
Patient presented with multiple reddish-brown papules and nodules.
Crucially, the patient exhibited no signs of arthritis at presentation.

Findings:

Systemic review excluded any associated malignancies.
Treatment with methotrexate was administered but yielded no therapeutic benefit.
The granulomatous infiltrate extended beyond the skin and synovium to involve other tissues.

Implications:

Highlights the varied clinical presentation of MCHR, which may not always include arthritis.
Underscores the importance of histological diagnosis for this rare histiocytic disorder.
Suggests that methotrexate may not be an effective treatment for MCHR, necessitating exploration of alternative therapies.

Related Experiment Videos