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Published on: August 8, 2025
[A new antimicrobial isobenzoisofuran compound from Cassia pumila]
Ling-Min Liao1, Qian Gao2, Yin-Ke Li1
1College of Chinese National Medicine, Yunnan Minzu University Kunming 650500, China Technology Center, China Tobacco Yunnan Industrial Co., Ltd. Kunming 650106, China.
Abstract:
A new isobenzoisofuran(1) has been isolated from the whole plant of Cassia pumila using various chromatographic techniques, including silica gel, Sephadex, MCI-gel resin, and RP-HPLC, and its structure was determined as 9-(2-hydroxyethyl)-2,2-dimethyl-2H-furo[3,4-g]chromen-6(8H)-one. This compound was also evaluated for its antibacterial activity. The results showed that it had prominent antibacterial activity with MIC_(90) value of(45.2±4.2) μg·mL~(-1) for methicillin resistant Staphylococcus aureus(MRSA) strain. This value was closed to that of levofloxacin [with MIC_(90) value(48.5±4.3) μg·mL~(-1)].
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