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Updated: Dec 25, 2025

Imaging and Quantification of the Area of Fast-Moving Microbubbles Using a High-Speed Camera and Image Analysis
Published on: September 5, 2020
A cost-effective, multi-flash, "ghost" imaging technique for high temporal and spatial resolution imaging of
Jonathan R Sukovich1, Scott C Haskell1, Zhen Xu1
1Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48105, USA.
Abstract:
This paper describes a method for acquiring high temporal and spatial resolution images of cavitation events using a multiple-flash-per-camera-exposure imaging technique. A primary challenge associated with imaging cavitation is that the velocity of the bubble wall reaches its maximum (∼1.5×103 m/s) as the bubble size approaches its minimum (≲1 μm). In order to adequately resolve dynamics on these scales, specialized-often prohibitively expensive-cameras with ultra-high frame-rates and resolutions are generally required. This paper describes low-cost, high-speed light emitting diode (LED) flash sources with minimum pulse widths of 20 ns that can be pulsed at rates of up to 17 MHz. The flashes are used to illuminate images of bubbles captured using high-resolution "still-frame" cameras wherein multiple flashes are issued from the LED(s) at known time intervals within a single camera exposure, resulting in overlapping snapshots of the same bubble at multiple unique time-points in a single image. The overlapping snapshots can be uniquely associated with the known time-points of the flashes based on their relative levels brightness. This paper demonstrate effective frame-rates up to 4 Mfps using this technique and the acquisition of snapshots at up to 13 unique time-points per exposure. Hardware descriptions of the flash sources and the programmable device used to control them are provided.
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