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Hereditary essential tremor in Buenos Aires (Argentina)
E Herskovits1, E Figueroa, C Mangone
1Hospital Juan A. Fernández, Unidad de Neurología Cerviño y Bulnes, Buenos Aires.
Arquivos De Neuro-Psiquiatria
|September 1, 1988
Summary
This study describes essential tremor in Buenos Aires, finding primidone and propranolol effective treatments. Essential tremor characteristics in this Latin American cohort align with global findings.
Area of Science:
- Neurology
- Clinical Trials
Background:
- Essential tremor is a common neurological disorder.
- Limited descriptive data exists for essential tremor in Latin America.
Purpose of the Study:
- To conduct a descriptive trial of essential tremor in Buenos Aires.
- To analyze semiological, clinico-evolutive, and therapeutic aspects of essential tremor.
- To compare findings with international essential tremor studies.
Main Methods:
- Descriptive study over 15 years.
- Inclusion of 39 patients from 16 families with essential tremor.
- Protocol-driven assessment of clinical features and treatment responses.
Main Results:
- Detailed analysis of clinico-evolutive characteristics including frequency, morbidity, mortality, prognosis, and triggering factors.
- Evaluation of various treatments, highlighting primidone and propranolol as first-line options.
- Pharmacokinetic and pharmacodynamic basis of treatments discussed.
Conclusions:
- Primidone (750 mg/daily) and propranolol (160-240 mg/daily) are the drugs of first choice for essential tremor.
- Essential tremor in Buenos Aires shares similar clinico-therapeutic features with populations in Europe and the USA.
- This study provides valuable epidemiological data for essential tremor in Latin America.