Related Experiment Video
Updated: Dec 25, 2025
Analysis of Microglia and Monocyte-derived Macrophages from the Central Nervous System by Flow Cytometry
Published on: June 22, 2017
Microglia and Other Myeloid Cells in Central Nervous System Health and Disease
Adithya Gopinath1, Anthony Collins2, Habibeh Khoshbouei2
1Department of Neuroscience, University of Florida College of Medicine, Gainesville, Florida adithya@ufl.edu.
Abstract:
Mononuclear macrophages derived from the bone marrow (myeloid cells) are key cellular components of the innate immune system in different organs. In this minireview, we are focused on both brain and blood macrophages, known as microglia and monocytes, respectively. We provide a succinct summary of the cells' functions under both normal and pathologic conditions, with particular reference to common neurodegenerative disorders, such as Alzheimer and Parkinson disease. SIGNIFICANCE STATEMENT: In this minireview, we aim to summarize available literature on microglial and myeloid involvement in CNS disease, directing the reader toward relevant and translatable interpretations of myeloid cell function in CNS health and neurodegeneration.
Insights
This review summarizes the roles of brain microglia and blood monocytes in neurodegenerative diseases like Alzheimer's and Parkinson's. Understanding these myeloid cells is crucial for CNS health and disease research.
Area of Science:
- Neuroimmunology
- Cellular Biology
- Innate Immunity
Background:
- Mononuclear macrophages, originating from bone marrow (myeloid cells), are vital innate immune cells in various organs.
- This review specifically examines brain microglia and blood monocytes, two key macrophage populations.
Purpose of the Study:
- To summarize the functions of microglia and monocytes in normal physiological states.
- To elucidate their roles in pathological conditions, particularly neurodegenerative disorders.
Main Methods:
- Literature review of existing research on myeloid cell function.
- Focus on studies related to Alzheimer disease and Parkinson disease.
Main Results:
- Myeloid cells, including microglia and monocytes, play significant roles in the central nervous system (CNS).
- Their functions are critical in both maintaining CNS health and contributing to neurodegeneration.
Conclusions:
- Microglial and myeloid cell involvement in CNS disease requires further investigation.
- Translating findings on myeloid cell function is key for understanding CNS health and neurodegeneration.
Related Concept Videos
01:04Glial Cells
01:31Nervous Tissue: Glial Cells
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...
01:25What is a Nervous System?