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Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore,  it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
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Editors' Note and Prologue

Evdokia Anagnostou1, Susan E Levy2, Micah O Mazurek3

  • 1Department of Pediatrics, Holland Bloorview Kids Rehabilitation Hospital and University of Toronto, Toronto, Canada.

Pediatrics
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No abstract available in PubMed .

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