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Use of C-Reactive Protein and Ferritin Biomarkers in Daily Pediatric Practice

Matthew D Taylor1, Vivek Allada2, Michael L Moritz3

  • 1Division of Critical Care Medicine, Cohen Children's Medical Center of New York, New Hyde Park, NY.

Pediatrics in Review
|April 3, 2020
PubMed

Insights

Pediatricians can use C-reactive protein (CRP) and ferritin biomarkers to assess inflammation. While useful in specific scenarios, further research is needed to standardize their application in clinical practice.

Area of Science:

  • Pediatric Clinical Research
  • Biomarker Analysis
  • Inflammation Studies

Background:

  • Multibiomarker models are increasingly used for risk stratification in pediatric clinical research.
  • C-reactive protein (CRP) and ferritin are widely available biomarkers in pediatric practice.
  • A comprehensive review of evidence supporting CRP and ferritin use in pediatrics is lacking.

Purpose of the Study:

  • To summarize existing evidence on the use of CRP and ferritin biomarkers in pediatric practice.
  • To initiate the development of a consensus for the future application of these biomarkers by pediatricians.
  • To provide a single-source resource for clinicians regarding these inflammatory markers.

Main Methods:

  • A systematic survey of all pediatric literature on CRP and ferritin available in PubMed was conducted.
  • Research relevant to daily pediatric clinical practice was summarized.
  • Contributions from pediatric subspecialists were integrated to describe biomarker use across various disease processes.

Main Results:

  • CRP and ferritin biomarkers exhibit diverse applications and varied cutoff values in the literature, complicating daily clinical use.
  • Elevated levels of CRP and ferritin correlate significantly with uncontrolled inflammation.
  • A clinical decision pathway and summarized evidence are presented.

Conclusions:

  • CRP and ferritin are widely utilized biomarkers in pediatrics.
  • Sufficient evidence supports the utility of these inflammatory biomarkers in guiding clinical decisions in specific pediatric cases.
  • Further research and standardization efforts are necessary to optimize the use of CRP and ferritin in routine pediatric clinical practice.

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