Related Experiment Video
Updated: Dec 25, 2025
07:41
Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
Published on: May 17, 2019
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Connection between SOX7 Expression and Breast Cancer Prognosis
Chun-Xin Qin1, Xiao-Qing Yang1, Zhi-Yong Zhan1
1Department of Thyroid Breast Surgery, Weihai Municipal Hospital, Weihai, Shandong, China (mainland).
Summary
SOX7 expression is reduced in breast cancer tissues, correlating with advanced disease. Lower SOX7 levels predict poorer overall survival, identifying SOX7 as a potential prognostic marker for breast cancer.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- SOX7 is known to suppress tumors and influence malignancies.
- Its role in breast cancer prognosis requires further investigation.
Purpose of the Study:
- To investigate the expression levels of SOX7 in breast cancer.
- To determine the association between SOX7 expression and clinicopathological features and patient outcomes.
Main Methods:
- Quantitative real-time-polymerase chain reaction (qRT-PCR) was used to measure SOX7 mRNA expression.
- Chi-square test, Kaplan-Meier method, and multivariate Cox regression were employed for analysis.
Main Results:
- SOX7 mRNA expression was significantly downregulated in breast cancer tissues compared to normal tissues (P<0.001).
- Reduced SOX7 expression correlated with larger tumor size (P=0.006) and lymph node metastasis (P=0.001).
- Low SOX7 expression was associated with shorter overall survival (OS) (P=0.005) and independently predicted OS (HR=3.956, P=0.013).
Conclusions:
- SOX7 expression is downregulated in breast cancer.
- SOX7 serves as a valuable prognostic biomarker for breast cancer patients.
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