Related Experiment Video
Updated: Dec 25, 2025
10:41
An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
Published on: April 5, 2018
10.7K
SPACE: a web server for linking chromatin accessibility with clinical phenotypes and the immune microenvironment in
Yingcheng Wu1,2, Jingwei Zhao1,3, Haoliang Zhu1,3
1Department of Pathogenic Biology, School of Medicine, Nantong University, Jiangsu, 226001, China.
Cellular & Molecular Immunology
|April 3, 2020
Abstract
No abstract available in PubMed .
Related Concept Videos
02:36Chromatin Immunoprecipitation- ChIP
12.0K
Chromatin immunoprecipitation, or ChIP, is an antibody-based technique used to identify sites on DNA that bind to transcription factors of interest or histone proteins. It also helps determine the type of histone modifications such as acetylation, phosphorylation, or methylation.
Types of ChIP
ChIP can be divided into two types - X-ChIP and N-ChIP. X-ChIP involves in vivo cross-linking of histones and regulatory proteins to DNA, fragmenting the DNA by sonication, and isolating the protein-DNA...
Types of ChIP
ChIP can be divided into two types - X-ChIP and N-ChIP. X-ChIP involves in vivo cross-linking of histones and regulatory proteins to DNA, fragmenting the DNA by sonication, and isolating the protein-DNA...
12.0K
02:25Spreading of Chromatin Modifications
9.2K
The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
Writers
The writer...
9.2K