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Myocarditis I: Introduction01:21

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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
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Infections causing stroke or stroke-like syndromes.

Pasquale Pagliano1, Anna M Spera1, Tiziana Ascione2

  • 1Department of Infectious Diseases, University of Salerno, Salerno, Italy.

Infection
|April 3, 2020
PubMed
Summary
This summary is machine-generated.

Infections can trigger stroke or mimic stroke symptoms, complicating diagnosis and treatment. Identifying infectious causes is crucial for appropriate management and improved patient outcomes.

Keywords:
EndocarditisInfectionInfluenzaMeningitisSepsisStrokeSyphilis

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Vascular Medicine

Background:

  • Stroke remains a significant cause of death and disability despite advances in treatment and diagnosis.
  • Infections, beyond common risk factors like diabetes and atrial fibrillation, can contribute to stroke by triggering inflammation and a pro-thrombotic state.
  • Infections can also manifest as stroke-like syndromes, necessitating high clinical suspicion for timely diagnosis.

Purpose of the Study:

  • To investigate the role of infections in stroke pathogenesis and presentation.
  • To highlight the diagnostic challenges associated with infectious stroke or stroke-like syndromes.
  • To emphasize the impact of accurate diagnosis on treatment strategies and patient outcomes.

Main Methods:

  • Review of clinical cases presenting with stroke or stroke-like syndromes.
  • Analysis of the etiological factors, focusing on infectious triggers.
  • Evaluation of treatment responses and outcomes in relation to the underlying cause.

Main Results:

  • Infectious origins were identified in a notable proportion of stroke or stroke-like syndromes with unknown causes.
  • Treatment of infectious stroke can be challenging, with standard therapies like Alteplase potentially increasing risks like hemorrhage.
  • Misdiagnosis, particularly in cases like endocarditis or meningitis, can lead to adverse outcomes due to inappropriate treatment.

Conclusions:

  • Stroke or stroke-like syndromes of infectious origin are significant and can present with sensory-motor deficits.
  • Accurate diagnosis of infectious causes is critical for selecting appropriate treatments and improving patient prognosis.
  • Recognizing and managing infections in stroke patients is essential for optimizing clinical outcomes.