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Fluoro-Substituted Methyllithium Chemistry: External Quenching Method Using Flow Microreactors
Marco Colella1, Arianna Tota1, Yusuke Takahashi2
1Department of Pharmacy-Drug Sciences, Flow Chemistry and Microreactor Technology FLAME-Lab, University of Bari "A. Moro", Via E. Orabona 4, 70125, Bari, Italy.
Abstract:
The external quenching method based on flow microreactors allows the generation and use of short-lived fluoro-substituted methyllithium reagents, such as fluoromethyllithium, fluoroiodomethyllithium, and fluoroiodostannylmethyllithium. Highly chemoselective reactions have been developed, opening new opportunities in the synthesis of fluorinated molecules using fluorinated organometallics.
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