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Related Experiment Video

Updated: Dec 25, 2025

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells

Published on: April 11, 2014

Angiostatic effects of ascorbic acid: current status and future perspectives.

Muhammad Torequl Islam¹

¹Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, 8100, Gopalganj, Bangladesh. dmt.islam@bsmrstu.edu.bd.

|April 3, 2020

Summary

Ascorbic acid (AA) shows anti-angiogenesis effects in various test systems, suggesting its potential as an angiostatic agent for cancer treatment. Further research is needed to confirm its therapeutic efficacy.

Keywords:

Angiogenesis Ascorbic acid Cancer

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Last Updated: Dec 25, 2025

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Area of Science:

Biochemistry
Cell Biology
Oncology

Background:

The anti-angiogenesis effect of ascorbic acid (AA) remains a subject of scientific debate.
Existing evidence indicates that AA exhibits anti-angiogenic properties across diverse biological models.

Discussion:

This paper reviews scientific data supporting the anti-angiogenesis role of AA.
The findings suggest AA's potential utility in inhibiting tumor blood vessel formation.

Key Insights:

Ascorbic acid demonstrates anti-angiogenesis effects in animal models, human subjects, and cell lines.
The evidence points towards AA's capacity to impede the development of new blood vessels.

Outlook:

Ascorbic acid presents a promising avenue as an angiostatic agent for cancer therapy.
Further clinical investigations are warranted to validate AA's therapeutic potential in oncology.