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Developing an Analytical Method Based on Graphene Quantum Dots for Quantification of Deferiprone in Plasma.
Raha Kaviani1,2, Saba Ghaffary3, Abolghasem Jouyban4,5,6
1Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Journal of Fluorescence
|April 3, 2020
Summary
A new, cost-efficient method uses graphene quantum dots (GQDs) to detect deferiprone in plasma. This fluorescence quenching technique offers a sensitive and selective approach for analyzing the drug.
Area of Science:
- Nanotechnology
- Analytical Chemistry
- Biomedical Sensing
Background:
- Graphene quantum dots (GQDs) are widely used in optical sensing and bioanalysis.
- Accurate quantification of deferiprone in plasma is crucial for therapeutic monitoring.
Purpose of the Study:
- To develop a simple, cost-efficient method for quantifying deferiprone in plasma samples.
- To utilize the selective interaction between GQDs, deferiprone, and Fe3+ ions for fluorescence sensing.
Main Methods:
- Synthesized GQDs using a bottom-up technique.
- Employed fluorescence quenching of GQDs induced by deferiprone in the presence of Fe3+ ions.
- Validated the method according to FDA guidelines for accuracy, precision, stability, and selectivity.
Main Results:
- A linear response was observed for deferiprone concentrations from 5 to 50 mg/L.
- The method demonstrated a sensitivity of 5 mg/L.
- The developed method showed high accuracy, precision, stability, and selectivity.
Conclusions:
- The developed method provides a green and low-cost fluorescent probe for deferiprone analysis.
- This approach is suitable for the quantification of deferiprone in plasma samples.
- The findings highlight the potential of GQDs in bioanalytical applications.
