Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Dec 25, 2025

Quantification of Hypopigmentation Activity In Vitro

Quantification of Hypopigmentation Activity In Vitro

Published on: March 6, 2019

Computational strategies towards developing novel antimelanogenic agents.

P Ambili Unni¹, S Sajitha Lulu¹, Girinath G Pillai²

¹School of Biosciences and Technology, Vellore Institute of Technology, Vellore, India.

|April 3, 2020

Summary

This study developed a validated Quantitative Structure-Activity Relationship (QSAR) model to identify novel compounds that inhibit tyrosinase, a key enzyme in skin hyperpigmentation. Eleven new derivatives show promising tyrosinase inhibition and bioavailability for potential anti-aging applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Metabolomic and systems biology insights into lead stress tolerance of Pennisetum purpureum bioaugmented with Enterobacter cloacae.

Archives of microbiology·2025

Same author

Migraine is a dysfunction of neuronal potassium ion channels.

Frontiers in neurology·2025

Same author

Targeting key players in Alzheimer's disease: bioactive compounds from <i>Moringa oleifera</i>, <i>Desmodium gangeticum</i>, and <i>Centella asiatica</i> as potential therapeutics.

Journal of biomolecular structure & dynamics·2024

Same author

Identification of potential phytochemical inhibitors for the proven six chronic obstructive pulmonary disease biomarkers - A molecular dynamics study.

Journal of biomolecular structure & dynamics·2023

Same author

Molecular crosstalk between COVID-19 and Alzheimer's disease using microarray and RNA-seq datasets: A system biology approach.

Frontiers in medicine·2023

Same author

Design, Synthesis, and Molecular Docking Studies of Curcumin Hybrid Conjugates as Potential Therapeutics for Breast Cancer.

Pharmaceuticals (Basel, Switzerland)·2022

Area of Science:

Medicinal Chemistry
Computational Chemistry
Dermatology

Background:

Extrinsic aging (photoaging) causes skin hyperpigmentation due to UV exposure.
UV radiation increases tyrosinase enzyme production, leading to melanin synthesis and hyperpigmentation.
Tyrosinase inhibition is a key target for treating hyperpigmentation.

Purpose of the Study:

To develop a validated Quantitative Structure-Activity Relationship (QSAR) model for tyrosinase inhibition.
To elucidate physicochemical properties crucial for tyrosinase inhibition.
To identify novel lead molecules with enhanced tyrosinase inhibitory activity and bioavailability.

Main Methods:

Lead optimization and in silico approaches were utilized.
A QSAR model was generated and validated using Multiple Linear Regression.

Keywords:

Antimelanogenic Lead optimization QSAR modelling Tyrosinase inhibition

More Related Videos

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

A Melanoma Patient-Derived Xenograft Model

A Melanoma Patient-Derived Xenograft Model

Published on: May 20, 2019

Related Experiment Videos

Last Updated: Dec 25, 2025

Quantification of Hypopigmentation Activity In Vitro

Quantification of Hypopigmentation Activity In Vitro

Published on: March 6, 2019

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

A Melanoma Patient-Derived Xenograft Model

A Melanoma Patient-Derived Xenograft Model

Published on: May 20, 2019

Molecular docking, bioavailability assessment, and toxicity prediction were performed for 69 thio-semicarbazone derivatives.

Main Results:

Molecular descriptors highlighted the importance of chemical properties for chelating copper ions in the tyrosinase active site.
Derivatives with electron-donating groups showed predicted tyrosinase inhibitory activity.
In silico methodologies, including chemical space exploration, were used for analysis.

Conclusions:

A validated QSAR model with high external predictive ability for tyrosinase inhibition was generated.
Eleven novel derivative compounds exhibiting enhanced tyrosinase inhibitory activity and bioavailability were proposed.
The findings offer potential for developing new treatments for skin hyperpigmentation.