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Updated: Dec 25, 2025
11:22
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
30.9K
Microbiota and metabolites in rheumatic diseases
Yanli Tong1, Tony Marion2, Georg Schett3
1Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Autoimmunity Reviews
|April 3, 2020
Summary
The human microbiota and its metabolites significantly influence rheumatic diseases. Understanding these interactions offers new avenues for diagnosis, therapy, and prevention strategies.
Area of Science:
- Microbiology
- Immunology
- Rheumatology
Background:
- The human microbiota plays crucial roles in health and disease, including immune system regulation.
- Advances in omics and bioinformatics enhance understanding of host-microbe interactions.
- Gut microbial metabolites impact various diseases, including rheumatic conditions.
Purpose of the Study:
- To review current knowledge on how microbiota and metabolites influence rheumatic diseases.
- To highlight the mechanistic interplay between microbes, metabolites, and the host in rheumatic diseases.
Main Methods:
- Literature review of recent studies on microbiota, metabolites, and rheumatic diseases.
- Analysis of mechanistic insights into host-microbe-metabolite interactions.
Main Results:
- Microbiota and their metabolites are implicated as key regulators in the development and progression of rheumatic diseases.
- Specific microbial metabolites can act as immune regulators or initiators in disease pathogenesis.
Conclusions:
- Elucidating the complex interplay between microbiota, metabolites, and the host is crucial for advancing rheumatic disease research.
- This understanding may lead to novel diagnostic, therapeutic, and preventive strategies for rheumatic diseases.
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