Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Factors Influencing Weight Gain at Different Stages of the Fontan Pathway for Children with Functionally Single Ventricle Heart Disease.

Pediatric cardiology·2026
Same author

Reduced regadenoson dose using heart rate-targeted titration in paediatric stress perfusion CMR.

European heart journal. Imaging methods and practice·2026
Same author

Feeding practices and nutritional management of infants with transient and congenital hyperinsulinism: A tertiary single-center retrospective study.

Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition·2026
Same author

Gastric Residual Volume Assessment in Critically Ill Children: The GASTRIC-PICU Randomized Clinical Trial.

JAMA·2026
Same author

Protocol for a Randomized Clinical Trial to Evaluate Not Routinely Measuring Gastric Residual Volume to Guide Enteral Feeding Versus Routine Measurement in Mechanically Ventilated Critically Ill Children (GASTRIC-PICU).

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·2026
Same author

Vascular and inflammatory diseases after COVID-19 infection and vaccination in children and young people in England: a retrospective, population-based cohort study using linked electronic health records.

The Lancet. Child & adolescent health·2025

Related Experiment Video

Updated: Dec 25, 2025

Echocardiographic Characterization of Left Ventricular Structure, Function, and Coronary Flow in Neonate Mice
07:55

Echocardiographic Characterization of Left Ventricular Structure, Function, and Coronary Flow in Neonate Mice

Published on: April 7, 2022

3.5K

Faecal calprotectin concentrations in neonates with CHD: pilot study.

Graeme O'Connor1,2, Katherine L Brown1,2, Andrew M Taylor1,2,3

  • 1Heart and Lung Department, Cardiothoracic Intensive Care Unit, Great Ormond Street Children's Hospital, London, UK.

Cardiology in the Young
|April 4, 2020
PubMed
Summary

Faecal calprotectin may indicate gut inflammation in neonates with congenital heart disease (CHD). Elevated levels correlate with necrotising enterocolitis (NEC), aiding early detection and management in at-risk infants.

Keywords:
CHDfaecal calprotectinfeedingnecrotising enterocolitissuspected necrotising enterocolitis

More Related Videos

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

4.1K
Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates
08:32

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates

Published on: February 17, 2023

1.6K

Related Experiment Videos

Last Updated: Dec 25, 2025

Echocardiographic Characterization of Left Ventricular Structure, Function, and Coronary Flow in Neonate Mice
07:55

Echocardiographic Characterization of Left Ventricular Structure, Function, and Coronary Flow in Neonate Mice

Published on: April 7, 2022

3.5K
A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

4.1K
Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates
08:32

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates

Published on: February 17, 2023

1.6K

Area of Science:

  • Neonatalogy
  • Pediatric Surgery
  • Gastroenterology

Background:

  • Neonates with congenital heart disease (CHD) face increased risk of necrotising enterocolitis (NEC) due to mesenteric hypoperfusion.
  • NEC leads to feeding interruptions, poor growth, and increased mortality risk in neonates with CHD.
  • Abdominal radiography has limitations in early NEC detection, particularly when pneumatosis intestinalis is absent.

Purpose of the Study:

  • To investigate the correlation between fecal calprotectin concentration and gut inflammation in neonates with CHD.
  • To assess the utility of fecal calprotectin as a biomarker for NEC in this vulnerable population.

Main Methods:

  • Prospective single-center study of term neonates with duct-dependent CHD (March 2018-March 2019).
  • Measurement of fecal calprotectin concentrations using enzyme-linked immunosorbent assay (ELISA) in post-surgical patients.
  • Analysis included 30 patients, comparing calprotectin levels across NEC, suspected NEC, and no NEC groups.

Main Results:

  • Significantly higher fecal calprotectin concentrations in neonates with NEC (3528 µg/g) and suspected NEC (1339 µg/g) compared to those without (390 µg/g) (p=0.0001).
  • Patients with suspected NEC experienced a longer hospital stay (average 18 days longer) (p=0.03).
  • Elevated calprotectin levels may reflect the severity of gut inflammation.

Conclusions:

  • Fecal calprotectin shows promise as a non-invasive biomarker for detecting and assessing gut inflammation in neonates with CHD.
  • Higher calprotectin levels are associated with NEC and suspected NEC, potentially indicating increased disease severity.
  • Early identification of NEC through biomarkers like calprotectin could lead to timely interventions, reducing prolonged nil-by-mouth periods and hospital stays.