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Related Experiment Video

Updated: Dec 25, 2025

Direct Pressure Monitoring Accurately Predicts Pulmonary Vein Occlusion During Cryoballoon Ablation
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Second-generation cryoballoon-based pulmonary vein isolation: Lessons from a five-year follow-up.

Christian-Hendrik Heeger1, Behnam Subin2, Erik Wissner3

  • 1University Heart Center Lübeck, Medical Clinic II (Department of Cardiology, Angiology and Intensive Care Medicine), University Hospital Schleswig-Holstein, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Lübeck, Germany; Department of Cardiology, Asklepios Klinik St. Georg, Hamburg, Germany.

International Journal of Cardiology
|April 4, 2020
PubMed
Summary
This summary is machine-generated.

Five-year outcomes for cryoballoon (CB2) pulmonary vein isolation (PVI) show a 54.4% success rate for atrial fibrillation (AF) patients. Repeat procedures increased success to 66.2%, with no difference between bonus freeze protocols.

Keywords:
Atrial fibrillationCryoballoonLong-term follow-upPulmonary vein isolation

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Area of Science:

  • Electrophysiology
  • Cardiology
  • Medical Devices

Background:

  • Second-generation cryoballoon (CB2) pulmonary vein isolation (PVI) shows promise for atrial fibrillation (AF) treatment.
  • Long-term clinical outcome data for CB2-based PVI is limited.
  • This study evaluates five-year outcomes of CB2-PVI in paroxysmal AF (PAF) and persistent AF (PersAF) patients.

Purpose of the Study:

  • To assess the five-year clinical outcomes of CB2-based PVI.
  • To compare outcomes between PAF and PersAF patients.
  • To evaluate the impact of bonus freeze protocols on long-term success.

Main Methods:

  • 139 patients (105 PAF, 34 PersAF) underwent index CB2-PVI with a 240-second freeze-cycle duration.
  • A bonus freeze-cycle was applied in 71 patients; it was omitted in 68 patients.
  • Clinical outcomes were assessed at a median follow-up of 60 months.

Main Results:

  • Single-procedure success rate at five years was 54.4% (62% for PAF, 46.9% for PersAF).
  • Overall success rate increased to 66.2% after repeat radiofrequency ablation procedures (69.2% for PAF, 65.6% for PersAF).
  • No significant difference in outcomes was observed between bonus-freeze and no-bonus-freeze protocols (53.5% vs 57.4%).

Conclusions:

  • The five-year single-procedure success rate for CB2-PVI is 54.4%, increasing to 66.2% with repeat procedures.
  • Outcomes differ significantly between PAF and PersAF patients.
  • Bonus freeze protocols did not impact long-term success rates.