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Updated: Dec 25, 2025

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
A Syndrome of Apparent Renal Failure
Marie A Z Simler1, Elsayed Desouky2, Fady Zakharious2
1Departments of Medicine and Cardiology, Wexham Park Hospital, Frimley Health NHS Foundation Trust, Slough, UK; Department of Medicine, Mater Dei Hospital, Msida, Malta.
Abstract:
Pseudo-azotemia is the syndrome of hypercreatininemia and hyperkaliemia without a change in glomerular filtration rate or structure of the kidney. A 57-year-old vulnerable woman with learning difficulties experienced an intraperitoneal bladder rupture in the absence of a pelvic fracture after a fall. It is suspected that the blunt force compression of a distended bladder situated above the bony protection of the pelvis resulted in delayed intraperitoneal bladder rupture. Urinary ascites resulted in pseudo-azotemia because of urinary creatinine reabsorption across the peritoneum. This "apparent" renal failure is fully reversible when diagnosis and treatment are prompt, with normalization of abnormal laboratory-investigation results often within 24 hours.
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