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Reticulin staining pattern in the differential diagnosis of benign parathyroid lesions
F Kuşku Çabuk1, M Sar2, D Canoğlu2
1Department of Pathology, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey. fatmagulkusku@hotmail.com.
Journal of Endocrinological Investigation
|April 4, 2020
Summary
Reticulin staining patterns (RSP) aid in distinguishing parathyroid lesions. A nodular dominant RSP suggests adenomas over hyperplasia, while short thick fibers indicate abnormal tissue versus normal glands.
Area of Science:
- Endocrinology
- Histopathology
- Oncology
Background:
- Reticulin staining patterns (RSP) are valuable for diagnosing endocrine gland lesions.
- Previous studies have explored RSP in adrenal and hypophysis glands.
Purpose of the Study:
- To investigate the utility of RSP in the differential diagnosis of parathyroid gland lesions.
- To correlate specific RSP with parathyroid adenomas, hyperplasia, and normal tissue.
Main Methods:
- Analysis of 97 parathyroid lesions and 29 normal parathyroid glands.
- Reticulin staining using a silver impregnation-based kit.
- Classification of RSP into short thick fiber, anastomosing, and nodular/alveolar patterns, with dominance defined as >50% of the section.
Main Results:
- Nodular dominant RSP was significantly associated with parathyroid adenomas compared to hyperplasia (p=0.049).
- Short thick fibers were observed in adenomas and hyperplasia but not in normal parathyroid glands (p<0.001).
- Alveolar patterns were absent in adenomas and never dominant in hyperplasia.
Conclusions:
- RSP is a useful tool for the differential diagnosis of parathyroid lesions.
- Short thick reticular fibers support the presence of adenomas or hyperplasia over normal tissue.
- A nodular dominant pattern is indicative of parathyroid adenoma rather than hyperplasia.
