Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Results of a pilot project of e-consultation from primary care to a movement disorders unit in a tertiary hospital].

Semergen·2026
Same author

Multivariate assessment of groundwater contamination levels associated with saline intrusion processes in Mediterranean coastal aquifers.

Journal of contaminant hydrology·2026
Same author

[Delayed breast reconstruction using DIEP flap without skin paddle: Technique, evaluation and management].

Annales de chirurgie plastique et esthetique·2025
Same author

Gene Expression Modulation in Bovine Endometrial Cells Infected with Gammaherpesvirus Type 4 and Exposed to Lipopolysaccharide in the Presence of Platelet-Rich Plasma.

Viruses·2025
Same author

Modelling occurrence and environmental risk of azithromycin in an intermittent river: Applying hydrological and water quality models.

Journal of contaminant hydrology·2025
Same author

Experimental Generation of Extreme Electron Beams for Advanced Accelerator Applications.

Physical review letters·2025

Related Experiment Video

Updated: Dec 25, 2025

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

9.2K

[Bases of deep brain stimulation].

C V Torres1, L López-Manzanares1, P Pulido-Rivas1

  • 1Hospital Universitario de la Princesa, 28006 Madrid, España.

Revista De Neurologia
|April 4, 2020
PubMed
Summary

Deep brain stimulation (DBS) is an effective therapy, but its precise mechanisms remain unclear. Research suggests DBS primarily corrects abnormal neural firing patterns in brain circuits to achieve therapeutic effects.

More Related Videos

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
09:46

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

11.3K
Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery
12:04

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

13.4K

Related Experiment Videos

Last Updated: Dec 25, 2025

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

9.2K
Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
09:46

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

11.3K
Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery
12:04

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

13.4K

Area of Science:

  • Neuroscience
  • Neuromodulation
  • Medical Technology

Background:

  • Deep brain stimulation (DBS) is an increasingly utilized therapy for various neurological and psychiatric conditions.
  • The precise mechanisms underlying DBS's therapeutic efficacy are not fully understood.
  • Evidence suggests DBS influences neural activity at multiple levels, from molecular to network scales.

Purpose of the Study:

  • To conduct a comprehensive review of the existing literature on the mechanism of action of deep brain stimulation.
  • To synthesize current knowledge regarding how DBS exerts its therapeutic effects.

Main Methods:

  • Literature review of studies investigating DBS mechanisms.
  • Analysis of DBS effects at molecular, cellular, and neural network levels.
  • Consideration of spatial, temporal, and electrical parameters influencing DBS effectiveness.

Main Results:

  • Deep brain stimulation (DBS) appears to function by modulating neural activity across different biological scales.
  • A primary mechanism involves the correction of anomalous firing patterns characteristic of neurological and psychiatric disorders.
  • Other potential mechanisms, including neuroprotection and neurogenesis, require further investigation.

Conclusions:

  • While many DBS mechanisms are still under investigation, it is recognized as a complex intervention with widespread brain effects.
  • The prevailing mechanism of action for DBS seems to be the correction of circuitopathies.
  • Further research is needed to fully elucidate the multifaceted actions of DBS.