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Updated: Dec 25, 2025

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
[Adherence to treatment with erythropoiesis stimulating agents]
C Pérez Díez1, H Navarro Aznárez, L M Lou Arnal
1Servicio de Farmacia Hospital Universitario Miguel Servet Zaragoza. cperezd@salud.aragon.es.
Background:
To establish adherence to treatment with erythropoiesis stimulating agents (ESA) in patients with anemia associated to chronic kidney disease (CKD), and analyze its relationship to response to ESA.
Methods:
Retrospective study of a cohort of 198 patients with CKD who started treatment with epoetin-ß or darbepoetin-a, followed for two years. Basal characteristics, effectiveness (% of hemoglobin (Hb) target attainment, percentage increase of Hb) and adherence (medication possession rate) were registered. A non-adherent patient was one whose mean adherence was <90%.
Results:
Average global adhesion was 89.6%, slightly higher in treatment with darbepoetin-a than with epoetin-ß; 8.6% of patients were non-adherents. Hb target was accomplished in 87% cases. Level of response to ESA treatment was independent of the degree of adherence to treatment.
Conclusions:
Adherence to ESA treatment was good, without differences related to degree of response.
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