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Related Experiment Video

Updated: Dec 25, 2025

A Chronic Cardiac Ischemia Model in Swine Using an Ameroid Constrictor
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A calcified chronic total occlusion preclinical model.

Azriel B Osherov1,2, Beiping Qiang1, Jagdish Butany3,4

  • 1Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|April 4, 2020
PubMed
Summary

This study developed a calcified chronic total occlusion (CTO) model in rabbits using diet and local injections. The model successfully created calcified CTOs, crucial for testing new treatments for heavily calcified artery blockages.

Keywords:
calcificationchronic total occlusionspercutaneous coronary interventionpreclinical animal model

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Preclinical Models

Background:

  • Percutaneous revascularization of chronic total occlusions (CTOs) often fails in cases of severe calcification.
  • A reliable preclinical model of calcified CTO is essential for developing novel treatment strategies.

Purpose of the Study:

  • To establish an experimental model of chronic total occlusion (CTO) with significant calcification.
  • To achieve calcification through dietary modifications and local pro-calcification factor injections.

Main Methods:

  • Chronic total occlusions (CTOs) were induced in rabbit femoral arteries using a thrombin injection model.
  • Dietary interventions included high cholesterol, calcium carbonate, and vitamin D supplementation.
  • Local injections of bone morphogenetic protein-2 (BMP-2), dipotassium phosphate, and calcium chloride were administered in select animals.

Main Results:

  • CTOs exhibited chronic inflammation and fibrosis.
  • Mineralization (calcification/ossification) was observed in 78% of arteries with calcium/vitamin D supplementation, appearing as early as 2 weeks.
  • Mineralization occurred in 85% of BMP-2 treated arteries and 60% of non-BMP-2 treated arteries.

Conclusions:

  • Dietary supplementation with calcium and vitamin D, alongside cholesterol, effectively induces complex mineralization in preclinical CTO models.
  • This model provides a valuable platform for evaluating new approaches to treat calcified CTOs.