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Published on: January 13, 2017
Microketides A and B, Polyketides from a Gorgonian-Derived Microsphaeropsis sp. Fungus
Yun-Feng Liu1,2, Ya-Hui Zhang1,2, Chang-Lun Shao1,3
1Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy; Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao 266003, People's Republic of China.
Abstract:
Microketides A and B (1 and 2), a pair of new C-11 epimeric polyketides, were obtained from the gorgonian-derived fungus Microsphaeropsis sp. RA10-14 collected from the South China Sea. The absolute configurations of 1 and 2 were assigned by the modified Mosher's method, TDDFT-ECD, and NMR calculations. Compounds 1 and 2 were evaluated for antibacterial, antifungal, and growth inhibition of marine phytoplankton activities. Microketide A (1) exhibited promising inhibitory activity against Pseudomonas aeruginosa, Nocardia brasiliensis, Kocuria rhizophila, and Bacillus anthraci with the same MIC value as ciprofloxacin (0.19 μg/mL).
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